（中 文）人类遗传学

Teacher

1、Wei Liu   2、Di Yu  3、Kaixiong Ye 4、Lu Chen

First day of classes

2 July, 2024（2024年7月2日）

Last day of classes

26 July, 2024 (2024年7月26日)

Course Credit

2 credits

Course Description

Course Introduction

Maintenance of a competent but balanced immune system is the cornerstone of health. The sophisticated immune defense mechanisms are essentially orchestrated by T cells. Not only can T cells directly kill infected and cancerous cells, but they also, through multiple subsets, fundamentally control the activation and function of other immune cell types. Therefore, targeted regulation of T cells subsets can efficiently modulate immune responses to treat many human diseases. The class also urges students to understand the basic concepts of epigenetic mechanisms, in particular DNA methylation and histone modifications, and to appreciate the clinical applications of cancer epigenetic therapy, diagnosis and prognosis. In the final session, we will discuss the molecular immunology and how to prepare yourself as a future scientist.

Objective

The differentiation of CD4 T cell functional subsets; CD4 T cells in human diseases; The discovery of Tfh cells; The evolution of IL-2 immunotherapy; The activation and differentiation of CD8 T cells; Research tools for CD8 T cells; Cancer Immunotherapy, focusing on immune checkpoint inhibition; The discovery of Tfc cells; Understand the concept of epigenetics; Learn the epigenetic mechanism(s) underlying cancer development and the recent and potential epigenetic applications in clinics.

Assignments (essay or other forms)

The course will be delivered in a discussion-based format, with each one focusing on a specific topic related to the course theme. The instructor will assign two to three pre-lecture readings, prior to this session students should prepare and study the readings.

Text Books and Reading Materials

1. https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(13)01148-3  

2. https://www.encodeproject.org/

3. http://www.roadmapepigenomics.org

4. http://www.blueprint-epigenome.eu/

5. Advice To A Young Scientist, by P.B.Medawar.

6. The Double Helix: A Personal Account of the Discovery of the Structure of DNA, by James D. Watson.

7. What Mad Pursuit: A personal View of Scientific Discovery, by Francis Crick.

Winning The Game Scientists Play, by Carl Sindermann

Faculty：College   of Life Sciences

Targeted Student：Undergraduate   students

Course Credit：2

Lecture Hours：32

（consisted of _32_ theoretical   hours and __0_ practical hours）

Course Leader：

Name：Zhixiong   Xie

E-mail：zxxie@whu.edu.cn

Office：Room No. 3129, College of Life   Sciences

Mobile：

Course Staff：

Name：Di Yu

E-mail：di.yu@anu.edu.au

Office：131 Garran Road  

Acton, ACT, 2601 Australia

Mobile：

Course Staff：

Name：Wei Liu

E-mail：w.liu@asu.edu

Office：Arizona State University

Mobile：

Course Staff：

Name：Kaixiong   Ye

E-mail：kaixiong.ye@uga.edu

Office：120 East   Green Street, Athens, GA 30602

Mobile：

Course Staff：

Name：Lu Chen

E-mail：Lu.Chen@fccc.edu

Office：W246 Lab location: W247

Lab Mobile：

Course Type：专业选修课程 Optional Specialty Course

Related Preview Courses：

None.

The differentiation of CD4 T cell functional   subsets;

1

CD4 T cells in human diseases;

1

The discovery of Tfh cells;

1

The evolution of IL-2 immunotherapy;

1

The activation and differentiation of CD8 T cells;

2

Research tools for CD8 T cells;

2

Cancer Immunotherapy, focusing on immune   checkpoint inhibition;

2

The discovery of Tfc cells;

2

Understand the concept of epigenetics;

2

Learn the epigenetic mechanism(s) underlying   cancer development and the recent and potential epigenetic applications in   clinics.

2

Cancer epigenetics: basic principles and clinical translation

2

Genome-wide epigenetic analysis

2

The differentiation of CD4 T cell functional subsets

2

CD4 T cells   in human diseases

2

The discovery of Tfh cells

2

The evolution of IL-2 immunotherapy

2

The activation and differentiation of CD8 T cells

2

L6: Research tools for CD8 T cells

2

L7: Cancer Immunotherapy, focusing on immune   checkpoint inhibition

2

L8: The discovery of Tfc cells

2