Faculty：College of Life Sciences

Targeted Student：Undergraduate students

Course Credit：2

Lecture Hours：32

（consisted of_32_theoretical hours and__0_practical hours）

Course Type：专业选修课程Optional Specialty Course

Related Preview Courses：

None.

The differentiation of CD4 T cell functional subsets;

1

CD4 T cells in human diseases;

1

The discovery of Tfh cells;

1

The evolution of IL-2 immunotherapy;

1

The activation and differentiation of CD8 T cells;

2

Research tools for CD8 T cells;

2

Cancer Immunotherapy, focusing on immune checkpoint inhibition;

2

The discovery of Tfc cells;

2

Understand the concept of epigenetics;

2

Learn the epigenetic mechanism(s) underlying cancer development and the recent and potential epigenetic applications in clinics.

2

Cancer epigenetics: basic principles and clinical translation

2

Genome-wide epigenetic analysis

2

The differentiation of CD4 T cell functional subsets

2

CD4 T cells in human diseases

2

The discovery of Tfh cells

2

The evolution of IL-2 immunotherapy

2

The activation and differentiation of CD8 T cells

2

L6: Research tools for CD8 T cells

2

L7: Cancer Immunotherapy, focusing on immune checkpoint inhibition

2

L8: The discovery of Tfc cells

2

（中文）人类遗传学

Teacher

1、Wei Liu 2、Di Yu 3、4、

First day of classes

2022年6月21日

Last day of classes

2022年7月15日

Course Credit

2

Course Description

Course Introduction

Maintenance of a competent but balanced immune system is the cornerstone of health. The sophisticated immune defence mechanisms are essentially orchestrated by T cells. Not only can T cells directly kill infected and cancerous cells, but they also, through multiple subsets, fundamentally control the activation and function of other immune cell types. Therefore, targeted regulation of T cells subsets can efficiently modulate immune responses to treat many human diseases. The class also urges students to understand the basic concepts of epigenetic mechanisms, in particular DNA methylation and histone modifications, and to appreciate the clinical applications of cancer epigenetic therapy, diagnosis and prognosis. In the final session, we will discuss the molecular immunology and how to prepare yourself as a future scientist.

Objective

The differentiation of CD4 T cell functional subsets; CD4 T cells in human diseases; The discovery of Tfh cells; The evolution of IL-2 immunotherapy; The activation and differentiation of CD8 T cells; Research tools for CD8 T cells; Cancer Immunotherapy, focusing on immune checkpoint inhibition; The discovery of Tfc cells; Understand the concept of epigenetics; Learn the epigenetic mechanism(s) underlying cancer development and the recent and potential epigenetic applications in clinics.

Assignments (essay or other forms)

The course will be delivered in a discussion-based format, with each one focusing on a specific topic related to the course theme. The instructor will assign two to three pre-lecture readings, prior to this session students should prepare and study the readings.

Text Books and Reading Materials

1.https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(13)01148-3

2.https://www.encodeproject.org/

3.http://www.roadmapepigenomics.org

4.http://www.blueprint-epigenome.eu/

5.Advice To A Young Scientist, by P.B.Medawar.

6.The Double Helix: A Personal Account of the Discovery of the Structure of DNA, by James D. Watson.

7.What Mad Pursuit: A personal View of Scientific Discovery, by Francis Crick.

Winning The Game Scientists Play, by Carl Sindermann